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An even more challenging task will be to elucidate the functional impact of such changes, both in terms of their quantitative influence on the biological activity of the affected protein, as well as their fractional control over the integrated network of subcellular and cellular regulation

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Within the TCA cycle, succinate is converted into fumarate by the succinate dehydrogenase (SDH) which represents the respiratory ETC complex II (CII) 73 (Supplementary Fig

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