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Phase I open label liver-directed gene therapy clinical trial for acute intermittent porphyria

189 In an uncontrolled trial that included 119 men with idiopathic infertility, supplementation with a multi-nutrient cocktail containing vitamins, minerals, and several antioxidants twice daily for three months led to significant improvements in sperm concentration, motility, morphology, and DNA fragmentation compared with pretreatment analyses

The lysate was carefully mixed for 10 minutes at 4 C and then centrifuged at 16,000 RCF for 30 minutes at 4 C
Med 4 , 101206 (2023)
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