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doi: 10.1016/j.jiph.2020.05.024, 28 ChoY

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Pentobarbital (ip, 100 mg/kg bw) was used to sacrifice the animals after the experiment

Kynurenine, a metabolite of tryptophan, upregulates T-cell PD-1 levels by inducing and activating the aryl hydrocarbon receptor (AhR), while AhR upregulates transporters to promote T cells to uptake kynurenine, forming a positive feedback loop and inhibiting anti-tumor immune responses (Liu et al., 2018)

Andrology 5 , 204218 (2017)