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Figure 1 shows how metformin can affect the absorption of vitamin B12

However, the study lacked in vivo validation and long-term stability assessments, highlighting the need for further preclinical investigation before clinical application

It helps avoid serious problems linked to B12 deficiency

It achieves this by inhibiting specific enzymes involved in the synthesis of purines and pyrimidines, which are essential building blocks for DNA and RNA

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A 2014 review by Seiwerth and colleagues in Current Pharmaceutical Design summarized the preclinical vascular effects attributed to BPC-157 and framed the mechanistic hypotheses that subsequent studies have tested