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Interleukin inhibitors Ustekinumab is an antagonist of the p40 subunit of pro-inflammatory cytokines interleukin-12 and interleukin-23, recently licensed for induction and maintenance therapy in CD and UC[9597]

As CD38 is expressed on the surface of early OC precursors, CD38 blocking may also prevent early OC formation [43]

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The authors pose that the expression of hypoxia-inducible factor 1 alpha in intestinal epithelial cells represents a crucial check point for the development of arthritis by impeding necroptosis of intestinal epithelial cells and safeguarding the intestinal barrier integrity

Emerging trends in pullulan-based antimicrobial systems for various applications

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