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In vitro evaluation of aptamer-based reversible inhibition of anticoagulant activated protein C as a novel supportive hemostatic approach

Consider IV therapy

Swallowing a peptide of this size means facing a gastrointestinal environment dense with proteases (trypsin, chymotrypsin, pepsin) that cleave peptide bonds in seconds to minutes

10.3389/fphys.2022.863347 27 HeQ.ZhuJ.YangG.LiuX.LiL.WangY.et al (2023)

Once patients found out how effective these medications were, word of mouth really drove up demand and outpaced the ability of these drug companies to manufacture them, says Nate Wood, MD, a primary care doctor and co-leader of the weight management clinic at the New Haven Primary Care Consortium, part of Yale New Haven Hospital in Connecticut

Du B, Jiao Q,Bai Y, Yu M,Pang M,Zhao M, Ma H,Yao H