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In SURMOUNT-1, adults with obesity or overweight without diabetes were randomized to tirzepatide or placebo for 72 weeks

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Keeping weight off after reaching a plateau, or trading a little effect for better tolerability or lower cost

Researchers planning matched-increment study designs can reference our Cagrisema titration protocol alongside the semaglutide dosing guide for non-clinical assay planning only

Nox4, NADPH oxidase 4

4.12 Proteomics and phosphoproteomics data analysis using Perseus Analysis for treatment versus untreated control of peptides and phosphopeptides was performed using Perseus v2.0.9.0