cofactor for glutathione peroxidase Glutathione-Related Enzymes and Proteins: A Review Proposed catalytic mechanism of glutathione

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However, a dysregulated increase in the level of these free radicals, as seen in mitochondrial diseases, can result in oxidative damage by overwhelming the cellular antioxidant defence mechanism, of which glutathione is the principal component [4]

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Methylcobalamin, being already in an active form, bypasses these conversion steps and can be utilised immediately by cells