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The human evidence is more limited and more mixed

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[10] found some 1-methylquinolinium scaffolds modified with primary amine substitutions displaying both high passive membrane diffusion in PAMPA and high active transport membrane permeability in a bidirectional permeability assay with Caco-2 cells, and one of them (5-amino-1-methylquinolinium (5-amino-1MQ)) has significant effectiveness against diet-induced obesity

[DOI] [PMC free article] [PubMed] [Google Scholar] 142.AlDahmani Z.M., Hadian M., RuizMoreno A.J., et al

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