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GDNF-expressing macrophages restore motor functions at a severe late-stage, and produce long-term neuroprotective effects at an early-stage of Parkinsons disease in transgenic Parkin Q311X(A) mice

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Cells were encapsulated into droplets and libraries prepared using the 10x Genomics platform (Hangzhou Cosmos Wisdom Biotech Co., Ltd.), and libraries were sequenced on an Illumina NextSeq

Further, histopathological analysis confirmed the biochemical findings

CD38 is one of the main NAD degrading enzymes in mammalian tissues, and plays a key role in age-related NAD decline

M., Shigematsu, Y., Jakobs, C