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doi: 10.1210/jc.2008-1595 14

Stimulates new blood vessel growth to improve nutrient delivery to injured tissues through VEGFR2 pathway activation Enhances fibroblast activity and collagen synthesis for stronger tissue repair and improved structural integrity Increases GH receptor expression making tissues more responsive to natural repair signals Modulates inflammatory response to reduce pain and prevent excessive tissue damage from prolonged inflammation Cell migration represents another critical mechanism
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Muscle capillary density increased by 15%20% through VEGF-mediated angiogenesis

Loren Pickart, who noticed something remarkable while studying human plasma

47,75,76,77 Recently, we reported that GH promotes radioresistance in cancer cell lines 78 and that pegvisomant suppresses endometrial tumor regrowth following radiotherapy in a xenograft model, which highlights the potential utility of this combinational approach and identifies GHR antagonism as a potential molecularly targeted radiosensitizing strategy
