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doi: 10.1161/JAHA.119.015576

Toll-like receptor-7 signaling promotes nonalcoholic steatohepatitis by inhibiting regulatory T cells in mice

doi: 10.1158/1055-9965.EPI-10-0180

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Additionally, TFRD reduced MDA and ROS levels in the serum and the expression of Notch1, Hes1 and PRDX1 proteins in femur tissues, suggesting that TFRD plays an anti-osteoporosis role by inhibiting the activation of the Notch1/Hes1/PRDX1 signalling pathway, alleviating oxidative stress injury, inhibiting osteoclastogenesis and bone resorption, promoting bone formation and regulating bone homeostasis