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Intriguingly, GOT1 and malic enzyme 1 (ME1) are also associated with redox homeostasis
GGT1 knockdown cell lines had minimal GGT1 mRNA (Extended Data Fig
& Laffey, J
In summary, UCP2 plays an active role in glutamine metabolism by transporting aspartate from the matrix to the cytosol for nucleotide synthesis and antioxidant production, thereby promoting tumor cell growth and survival
Kodym R, Calkins P and Story M
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