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If your B12 levels are already normal, extra supplementation may not significantly improve fatigue because the body usually eliminates excess B12

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Possible causes of high Hcy levels in psoriasis Generally speaking, deficiencies or genetic polymorphisms in the enzymes taking part in Hcy metabolism and insufficient amounts of cofactors are a major cause of HHcy, and excessive methionine intake, certain diseases, and certain drugs represent additional causes [24]

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