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A possible substrate of the glyoxalase system in the parasite is the glycolytic intermediate dihydroxyacetone phosphate that forms spontaneously the toxic electrophile methylglyoxal, an -oxoaldehyde

V.HernandezJ
10.3389/fcimb.2021.751232 58 SmerA.SquiresR

These results suggest that oxidative stress could play a contributing role in the development of cognitive problems
PMID 24231531

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