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In the subgroup analysis by outcome measures, there were no statistically significant groups (Fig

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Given that GABA is the primary inhibitory neurotransmitter, its deficiency can lead to severe consequences, such as seizures (, )

While in the majority of IBS patients, CNS-related precipitants in early and adult life (e.g., psychological trauma, stress, abuse, maternal neglect) 147 have been identified, about half of IBS patients present after an intestinal trigger 148

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