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Skin concerns: Dark circles (both pigmentation and vascular), fine lines and wrinkles around the eye, dehydration in this area, and puffiness

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(7, 8) During the oxidation of acetaldehyde into acetate by the aldehyde dehydrogenase enzyme (ALDH), excess NADH is produced which alters the proportion of NADH to NAD

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Future investigations should focus on the long-term safety and efficacy of GlyT1 inhibitors, particularly in combination with existing dopaminergic therapies, to optimize treatment strategies for the patients with Parkinsons disease