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Notably, IL-13 stimulates the production of 13-( S )-hydroxyoctadecadienoic acid [13-( S )-HODE] and 12-( S )-HETE by 12/15-LOX, leading to bronchial epithelial injury through oxidative stress and ROS production [40, 41]

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The upstream regulation of GPX4 mainly include transcription factors such as Nrf2 (Dodson et al., 2019), MYB (Hao et al., 2017), Tfap2c (Alim et al., 2019), Sp1 (Alim et al., 2019), Lipocalin 2 (LCN2) (Chaudhary et al., 2021), mTORC1 (Saxton and Sabatini, 2017

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