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2e), consistent with the morphological and histological findings and indicating sustained melanin production in adult transgenic but not in wild-type melanocytes

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Reductions in fat mass without concomitant lean mass losses and decreases in plasma leptin and insulin were noted with 53.4 nmol/day doses of AZD2820 ( AZD2820 entered a phase 1 clinical trial in 2011 to investigate the safety and tolerability in healthy male volunteers of single ascending doses up to 12 mg, SC QD ( Table 2 ) ( The absence of weight loss coupled with partial agonism on hMC4R suggests that an efficacious dose of AZD2820 was not achieved