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Elevated homocysteine has been linked to depression (Bottiglieri et al., 2000), cognitive decline, Alzheimers disease (Smith et al., 2010), and cardiovascular disease (Refsum et al., 2006)

To date, there were six clinical trials investigating its use, with approximately 900 people enrolled in total

In addition to GLP1, researchers identified another nutrientstimulated hormone, glucosedependent insulinotropic polypeptide (GIP), as a promising therapeutic target [4, 5]

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The daily 2,330 mcg dose is 10 units (0.10 mL)

Acknowledgements The authors would like to acknowledge the financial support from the University of Southern California (USC) Alfred Manning Institute (AMI) fellowship awarded to JW, the National Heart, Lung, and Blood Institute (NHLBI, R00HL124279) and NIH New Innovator Award (DP2-DK121328) awarded to EJC