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and airway secretions utilize GPx for local hydroperoxide detoxification

however, these findings highlight one of the complexities of using antioxidant therapies, as increased GPx1 activity was correlated with enhanced ERK1/2 activation when analyzing memory, whereas increased GPx1 correlated with a decrease in ERK1/2 activation in the hypoxic preconditioning study, presumably due to the loss of hydrogen peroxide-mediated ERK1/2 activation

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PMCID: PMC4911503

10.1155/2022/9106415 226 SharmaS.AwasthiA.SinghS

Furthermore, in cases where molecular disease pathology remains elusive, condensate-based phenotypic screening strategies can provide promising therapeutic options