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Upon developing our extended NMP protocol, our initial three perfusions failed in association with high levels of MetHb

However, negative feedback regulation has also been found

Such processes have been extensively reviewed elsewhere, but are summarized and integrated here

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Another clinical challenge is the TSHT3 mismatch: while TSH reflects central (pituitary) regulation, it does not necessarily correspond to peripheral thyroid hormone activity, especially in the altered hormonal environment induced by ketosis [114]