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Dandurand KR, Stennett DJ

SF-induced microglial activation in the hippocampus was related to dysregulation of autophagy [68]

Conversely, SSRIs such as paroxetine and fluvoxamine demonstrate non-linear pharmacokinetics, meaning that increased doses do not lead to proportionate increases in plasma concentrations

doi: 10.1093/brain/awac025

The activation of microglia is typically bifurcated into two distinct phenotypes: the M1 phenotype, which is linked to pro-inflammatory activities and neurotoxic responses, and the M2 phenotype, which is engaged in tissue repair and neuroprotective processes

Patients describe a profound, unrelenting exhaustion that does not improve with rest and is dramatically worsened by physical or cognitive exertion, a pattern called post-exertional malaise (PEM)
