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In the models, the CO 2 concentration was fixed at 2.2 mM, considering CO 2 dissolved in plasma oscillated between 1.2 and 2.4 mM ( 2 concentration was incorporated into the Keq value of the equations of the enzymes that produce it (PDH, IDH, 2OGDH) as the ratio Keq / [CO 2 ] ( Supplementary Table S1 )

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