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Physical exercise and particular nutrients, including CIT and leucine, have demonstrated efficacy in upregulating the signaling pathways of PGC-1, SIRT1, and AMPK, thereby facilitating mitochondrial turnover and alleviating oxidative stress (74)

doi: 10.3346/jkms.2014.2H9.1.2 36 LuM-CLaiN-SYuH-CHuangH-BHsiehS-CYuC-L

[DOI] [PubMed] [Google Scholar] 12.U.S

In: Katzung's Basic & Clinical Pharmacology, 16th Ed

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1 MCADD is typically diagnosed within the first two years of life and is characterized by hypoketotic hypoglycaemia and vomiting that may progress to seizures and coma in times of catabolic stress or prolonged fasting
