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Efforts to inhibit NRF2 include both large-scale drug screens to identify direct and indirect inhibitors, as well as approaches to exploit novel NRF2-specific metabolic dependencies

[DOI] [PMC free article] [PubMed] [Google Scholar] 133.Harris E

Another alternate glucose metabolism pathway, the hexosamine biosynthesis pathway (HBP), is also upregulated in AML patient samples

Animal studies have indicated the possibility of GANR as a Parkinson's disease treatment, where it has been proven to enhance motor performance and lessen the need for dopamine replacement therapy
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