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However, 3-KO mice failed to show any significant changes in body weight following treatment with AOD9604 or hGH

Therefore, IGF-1 deprivation seriously contributes to the progressive malnutrition of cirrhotic patients, increasing the vulnerability of the liver to an inflammatory and oxidative microenvironment with mitochondrial dysfunction

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Saraswat M, Musante L, Ravida A, Shortt B, Byrne B, Holthofer H

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