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This review focused on presenting new and promising mechanisms responsible for the potential antioxidant use of metformin, while forecasting further research directions (Salvatore et al., 2021)

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However, it appears quite probable that the vasodilatory effects of GPLC surpassed a beneficial magnitude in the 3.0 and 4.5 g/d groups

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Quality assessment Appendix: Table S2 presents the risk of bias of included RCTs for each outcome

In particular, we were unable to show a decrease in creatine, despite using the same design and MRS methodology, including the use of the same scanner and MRS sequences