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However, studies on the genetic and metabolic characteristics that are associated with healthy longevity and old age survival suggest that the conserved ancient IIS pathway may also play a role in human longevity

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The lack of nutrients also leads to the depletion of reducing agents like glutathione and thus to the overall reduction of antioxidative capacity in hepatocytes

doi: 10.1105/tpc.107.050849

This nitration impairs ALDH2 catalytic activity and contributes to nitrate tolerance (144)