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The solved crystal structure places the active site loop in a conformation which closely resembles the reduced `active state` of human succinic semialdehyde dehydrogenase

Dostinex is prescribed with caution to patients with cardiovascular diseases, Raynaud's syndrome, peptic ulcer or gastrointestinal bleeding, as well as patients with indications of a history of severe mental illness, especially psychosis

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Defective autophagy has been observed during aging and neurodegenerative disorders, supporting its fundamental role in advancing the progression of brain damage and cognitive decline (359)

Carillo, M., Bertapelle, C., Scial, F., Siervo, M., Spagnuolo, G., Simeone, M., Peluso, G., & Digilio, F

Neurologic considerations in propionic acidemia