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Implications on the dominant negative effect

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This action appears to result from a combination of mechanisms including: blocking Na+ channels (possibly the most important mechanism) enhancing GABA-mediated inhibition in the CNS (by increasing GABA levels by a variety of mechanisms) increase in K+ currents block of T-type Ca2+ channels blockade of excitatory NMDA receptor-mediated excitation NOTE: sodium valproate is the salt form of valproic acid

Such variations are not uncommon and have been reported in previous studies 37,38,39

Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2

R., Wei, W