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To further explore whether DA-related alterations were potential targets of GSH, we investigated the therapeutic effect of DA accumulation on ischemic brain injury

the first and second cysteines are disulfide bonded to each other because they were available first during protein translation

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Some proponents suggest that it may have a role in supporting body detoxification and metabolism

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Proteolytic digestions of Mpro revealed Cys300 as a primary target of glutathionylation, and experiments using a C300S Mpro mutant revealed that Cys300 is required for inhibition of activity upon Mpro glutathionylation