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This GHR upregulation sensitises local cells to circulating GH, potentiating GH-induced JAK2/STAT signalling and stimulating collagen matrix synthesis, IGF-1 production, and fibroblast proliferation providing a mechanism through which BPC-157 engages the GH/IGF-1 axis at the tissue level without altering systemic GH secretion

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potentially complementary effects Interaction research: No published studies evaluate interactions between these compounds Risk: Unknown synergistic or antagonistic effects

141,143148 Several lines of evidence have indicated that extracellular loops (EL1 and EL2) of claudins are important for both trans - and cis -claudinclaudin interactions