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The secretion of Th1 cytokines activates the release of enzymes such as matrix metalloproteinases that can damage the intestinal mucosa, with a loss of villous structure [21]

Berndt C, Lillig CH

4.3 Type 1 Diabetes Type 1 diabetes (T1D) is characterized by hyperglycemia and hypoinsulinemia and requires treatment with exogenous insulin therapy

However, precancerous cells can become cancerous

Oxidative stress and preterm birth

As we previously did find a clear increased large intestinal permeability, it would be interesting to investigate also other potential causative factors contributing to barrier dysfunction, such as changes in microbiota composition