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Fibromyalgia and Inflammation: unrevealing the connection

In PBMCs, citrullination of histone H3 at H3Cit8 prevents heterochromatin protein 1 binding to H3K9me3, thereby suppressing TNF- and IL-8 expression (63)

References: European Medicines Agency (EMA) (2024): OBGEMSA, INN-Vibegron - Summary of Product Characteristics

For instance, ROS-mediated activation of transcription factors such as NF-B orchestrates immune responses and inflammatory processes essential for host defense mechanisms [248]

It's crucial to monitor for any adverse reactions and seek medical attention if necessary

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