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As summarized in TABLE 5, at least seven different types of 5-HT receptor are expressed in the GI tract, and they are expressed on enteric neurons, extrinsic primary afferents, interstitial cells, smooth muscle cells, enteroendocrine cells, enterocytes, goblet cells, and immune cells, and some of these receptors exhibit constitutive activity

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Watanabe T, Sakai D, Yamamoto Y, Iwashina T, Serigano K, Tamura F, Mochida J: Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell-to-cell contact with autologous mesenchymal stem cells

I also discuss peptide sourcing, dosages, cycling, routes of administration, and how peptides work in combination

On average, it takes 2.1 years to recruit the populations for a Phase 1 trial, 2.5 years to recruit enough participants for a Phase 2 trial, and 3.2 years for recruitment of participants for a Phase 3 trial