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10.1016/j.molcel.2020.07.012 46 HuangP.HeZ.JiS.SunH.XiangD.LiuC.et al (2011)

Regula al alza los receptores de hormona del crecimiento a nivel tisular sin alterar las concentraciones sistemicas de GH o IGF-1

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Clinics can use different ingredient blends

A pharmaceutical formulation comprising: an effective amount of cagrilintide and semaglutide, more than 10% w/v and less than 22% w/v, such as 10-20% w/v cyclodextrin of the hydroxypropyl-substituted alpha and/or beta type, said cyclodextrin comprising a minimum of about 0.4 and a maximum of about 1.0 hydroxypropyls per glucose unit, such as 0.58-1 .0 hydroxypropyls per glucose unit, about 3-30 mM histidine, about 10-40 mg/ml sorbitol, up to 2.0 mg/ml, such as up to 1 .5 mg/ml polysorbate 20 and/or 80, about 75-90% w/w water and having a pH of 5.6-6.0