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These effects were associated with decreased androgen receptors, mTOR and AKT expression signaling, and increased caspase-3 activation 35

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Overall, accumulating evidence suggests that paternal diabetes can program offspring metabolic outcomes through stable, heritable epigenetic modifications
Curr Vasc Pharmacol (2019) 17(5):53840

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However, notable by their absence and as highlighted within many of the publications is the lack of robust effectiveness of evaluations in relation to interventions focused on the use of IPEDs