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Overproduction of ROS One hallmark feature of IBD is the overproduction of ROS, which causes dysregulation of signal transduction, an inflammatory response, and DNA damage, all of which contribute to the progression and deterioration of the disease (27)

10.3390/ijms22147613 124 Van HoutenJ

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A subsequent consensus review systematically organized and precisely defined the hallmarks of T-cell exhaustion [215]