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YAP-dependent necrosis occurs in early stages of Alzheimers disease and regulates mouse model pathology

It is defined by the interaction of free intracellular iron or iron-containing enzymes with oxygen and polyunsaturated fatty acids (PUFAs), resulting in high levels of membrane lipid peroxides [99]

NADPH oxidase-4 driven cardiac macrophage polarization protects against myocardial infarction-induced remodeling

Numerous preclinical studies on ASD mouse models contributed to the identification of new candidate drugs or other strategies to treat ASD in humans, including mGluR5 modulators, agmatine, rapamycin, oxytocin, supplementation with folate and vitamin B12, ketogenic diet, among others, thus confirming the relevance of this approach in translational ASD research

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