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Additionally, it has been shown that metformin affects mitochondrial activities dependent upon the model system studied

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The formation of this membrane associated enzyme complex results in the generation of superoxide anion which in turn is converted to hydrogen peroxide through the action of Cu-Zn superoxide dismutase (SOD1)

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Studies show that anthocyanins in black rice extract (0.5, 1.0 and 2.0 g/kg/day for 8 weeks) can improve bone loss in diabetes rats by inhibiting bone turnover and bone marrow fat production, and up regulating the ratio of RUNX2 and OPG/RANKL in bone tissue of diabetes rats (85)

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