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J Natl Compr Cancer Netw: JNCCN
TRP undergoes oxidation by the rate-limiting enzymes indoleamine 2,3-dioxygenase (IDO, found in various organs, including nerve cells) or tryptophan 2,3-dioxygenase (TDO, present in the liver), leading to the formation of kynurenine (KYN), 3-hydroxykynurenine (3-HK), and other products, ultimately resulting in quinolinic acid (QUIN) ( Figure 1 Serotonin (SER, also known as 5-hydroxytryptamine, 5-HT) is a neurotransmitter synthesized in small amounts from TRP in the brain and approximately 90% in the gastrointestinal tract ( Figure 1 )
Although acetaminophen is relatively safe at therapeutic doses, it can lead to liver failure
IL-6 Mediated JAK/STAT3 Signaling Pathway in Cancer Patients with Cachexia
[en lnea] Marzo de 2005 [fecha de acceso 4 de Octubre de 2017]
2021;99 doi: 10.1016/j.jtherbio.2021.103019
