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The authors suggested that imatinib favored the transport of hydroxyurea into the CNS by inhibiting P-gp-mediated efflux [332]

In this study, a high prevalence of DAO deficiency was observed in the migraine group (87%) and with a mean DAO activity significantly lower in comparison with that obtained from control volunteers

Mitochondria are also involved in key cellular functions such as Ca 2 + homeostasis, heme biosynthesis, nutrient metabolism (Cheng and Ristow, 2013), steroid hormone biosynthesis, removal of ammonia, integration of metabolic and signaling pathways for cell death and autophagy (Hammerman et al., 2004

Burden from concomitant use of ISTs was also reduced with use of eculizumab: mean prednisolone dose was reduced by 23.33 mg/day and all 6 patients on IVIg were able to wean off from IVIg successfully