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Ammonia accumulation has a dual effect on autophagy (109, 110)

Read counts were generated with R Studio function Summarize Overlaps and normalized to RPKM based on the number of uniquely mapped reads
doi: 10.15586/aei.v49i5.102

Neuroinflammation and oxidative stress in rostral ventrolateral medulla contribute to neurogenic hypertension induced by systemic inflammation

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Thus, HO-1 plays significant part in regulating the progression and application of DN (Fig