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This mechanism underscores NACs therapeutic potential in counteracting mercury-induced toxicity

doi: 10.1016/0002-9378(78)90019-4 [DOI] [PubMed] [Google Scholar] 347

In turn, oxalate promotes steatosis in hepatocytes by inhibiting peroxisome proliferator-activated receptor- (PPAR) transcription and fatty acid -oxidation and induces monocyte chemotaxis via CC motif chemokine ligand 2

Burton GJ, Yung HW, Cindrova-Davies T, Charnock-Jones DS: Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia

Similarly, paclitaxel induced down-regulation of several potassium channels, including K Ir 1.1, K Ir 3.4, and K 2P 1.1 (Zhang and Dougherty, 2014)

Recently, GPx4 was predicted to be a specific target for new pharmacological therapies aimed at activating or inhibiting cell death in cancer or degenerative diseases [110]