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Role of Mitochondria in Ferroptosis

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As with other amino-acid cofactor-containing enzymes, formation of the CDO Cys-Tyr cross-link required a transition metal cofactor [ferrous iron (Fe 2+ )] and oxygen (O 2 )], but unlike other amino-acid cofactor-containing enzymes, biogenesis of the CDO cross-link did not occur immediately upon exposure to metal and O 2, , was not essential for basal catalytic activity, and was strictly dependent upon the presence of its specific substrate Cys

These processes can also stimulate neuronal cell death through ferroptosis [244]

IGF-1 LR3 represents a well-characterised, research-grade analogue of human IGF-1, providing an extended-acting model for the study of growth-factor-mediated signalling

An independent validation of the selection was performed using AI-powered software ASReview (v1.5)