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During times of physiological stress, such as infection or surgery, patients require stress-dose glucocorticoids to prevent life-threatening cardiovascular collapse and severe hypoglycemia

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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Bhattacharjee S., Dashwood R.H

The most commonly used combined outcome is the Combined Assessment of Function and Survival (CAFS), which is a combined, nonparametric test assessing change of ALSFRS-R scores at multiple timepoints while accounting for survival, patient drop-out (censorship), or other prespecified time-to-event endpoints, similar to a rank sum model [49, 50]