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66 WangC

NRF2 protein stability is tightly regulated and its two main regulators are i) Kelch-like ECH-associated protein 1 (KEAP1) in the cytoplasm and ii) BTB and CNC homology 1 (BACH1) in the nucleus

Although the peptide is reported to be stable in gastric juice, its bioavailability may be lower with this route

doi: 10.1124/jpet.111.179317

M.MaD.BuelowK.YinL.LinJ

Some cytokines, such as TNF- and TGF-, increase mucin secretion through the interaction of the EGFR and reactive oxygen species pathways as well as generation of small nucleotides which trigger mucin granule exocytosis such as cyclic-di-GMP, ATP, or cAMP (Perez-Vilar et al., 2005