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Figure 2 2.2.2.2 BL regulates adaptive immunity in PD Postmortem analyses of PD patients and animal models consistently reveal significant blood-brain barrier disruption, accompanied by enhanced peripheral immune cell migration and prominent T cell infiltration (predominantly CD3 + , CD4 + , and CD8 + subsets) within the substantia nigra ( + T cell populations are reduced, whereas the suppressive activity of CD4 + FOXP3 + Tregs is augmented ( + T cells in PD patients specifically recognize -Syn epitopes, triggering FAS receptor-mediated apoptotic signaling and increased secretion of inflammatory mediators, including IL-10

Activation also requires the participation of the small G-protein Rac 1/2 and Rap 1A

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10.1371/journal.pone.0218409 125 ZhangB.HuoX.XuL.ChengZ.CongX.LuX.et al (2017)