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mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion

May be 6 months

Targeted co-delivery of the iron chelator deferoxamine and a HIF1 inhibitor impairs pancreatic tumor growth

Moxley RT, Arner P, Moss A, Skottner A, Fox M, James D, Livingston JN

Several factors, including cytokines, proteases, growth factors, gut microbiota, and dietary components are known to regulate intestinal TJs opening ( Intestinal epithelial cells and mononuclear phagocytes sense bacteria or their products mainly through pattern recognition receptors such as TLRs (166)

Typically, a two-step process is applied, where (1) the surface is plasma-treated with an air, O 2 , or N 2 plasma to remove volatile organic contamination and activate the surface with oxygen-containing functional groups, followed by (2) fluorinated or methylated plasma polymerization to generate a hydrophobic fluoropolymer or hydrocarbon coating